viral Encephalitis

Application of the treatment combined Western and traditional Chinese medicine in idiopathic uveo-encephalitis

CONCLUSION:

Xin, Hot, fried food and certain special protein may interfere with the human immunity, which may be the cause of the IUE in certain patients. Fundus fluorescein angiography is helpful in early diagnosis, the method of CWTCM is a efficient treatment, which values for further investigation.

Shuanghuanglian injection downregulates nuclear factor-kappa B expression in mice with viral encephalitis.

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Abstract

A mouse model of viral encephalitis was induced by intracranial injection of a Coxsackie virus B3 suspension. Quantitative real-time reverse transcription-PCR and western blot assay were applied to detect mRNA and protein expression of intelectin-2 and nuclear factor-kappa B in the viral encephalitis and control groups. Nuclear factor-kappa B and intelectin-2 mRNA and protein expression were significantly increased in mice with viral encephalitis. After intraperitoneal injection of Shuanghuanglian at a dose of 1.5 mg/kg for 5 successive days, intelectin-2 and nuclear factor-kappa B protein and mRNA expression were significantly decreased. To elucidate the relationship between intelectin-2 and nuclear factor-kappa B, mice with viral encephalitis were administered an intracerebral injection of 107 pfu recombinant lentivirus expressing intelectin shRNA. Both protein and mRNA levels of intelectin and nuclear factor-kappa B in brain tissue of mice were significantly decreased. Experimental findings suggest that Shuanghuanglian injection may downregulate nuclear factor-kappa B production via suppression of intelectin production, thus inhibiting inflammation associated with viral encephalitis.